Background Presenilin enhancer gamma-secretase subunit (PSENEN), the straight target of metformin, is highly expressed in several cancers.The role of PSENEN in kidney renal clear cell carcinoma (KIRC) has not been reported.Methods PSENEN expression in KIRC specimens was investigated in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO
The fatigue of pilots is the most threatening factor in aviation safety internationally, requiring continuous management.In order to prevent aircraft accidents that may occur due to fatigue, this paper analyzes fatigue-related accident cases and previous research and suggests ways to improve the fatigue management of pilots.Problems in major fatigu
The study of twins provides a unique opportunity to evaluate the genetic and nongenetic contributions to Fat Separators a variance of multitude of traits.Twin research has revealed the impact of a strong genetic component to the variance of many dental traits.The present study was conducted to assess the dental caries and oral hygiene status in mon
Background: Ultrabrief stimulation in electroconvulsive therapy (ECT) using a 0.25 or Bedding 0.30 ms pulse width markedly reduces the charge required to reach the seizure threshold (ST) and cognitive side effects.It is not known whether further reduction of pulse width to 0.15 ms is advantageous.Methods: Thirty-seven patients were randomized to ST